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Synthesis and biocompatibility of phosphorylcholine polymer membranes

Authors： LI Lin, XIN Zhong*, WANG Junhua

Units： State Key Laboratory of Chemical Engineering, School of chemical engineering, East China University of Science and Technology, Shanghai 200237, China

KeyWords： phosphorylcholine; platelet adhesion; equilibrium water content; biocompatibility

ClassificationCode：TQ316.6

year,volume(issue):pagination： 2012,32(1):40-45

Abstract：

2-methacryloyloxyethyl phosphorylcholine (MPC) was copolymerized with butyl methacrylate (BMA) and 2-ethylhexyl methacrylate (EHMA), respectively, using 2, 2’-azodiisobutyronitrile (AIBN) as the initiator, in order to research the biocompatibility of the phosphorylcholine polymers. The chemical structures of the polymers were characterized by the IR, 1H-NMR and elemental analyses. The solubility of the polymers in different solvents was also investigated, which provided the evidence for the purification of these polymers. Polymer membranes were prepared by solvent evaporation method. The platelet rich plasma (PRP) contact studies showed that the adhesion of platelets on the surfaces of MPC polymer membranes was reduced compared to the polymers without MPC unit, which showed good blood compatibility. The equilibrium water content (EWC) of the MPC polymer membranes increased with increases in the MPC mole fraction, and this value for PMB20 polymer membrane (MPC mole fraction: 18%) reached 47%. The high water content of phosphorylcholine polymers is one of the reasons for the good biocompatibility of the membranes.

Funds：

国家自然科学基金项目（21006025）

AuthorIntro：

李琳（1983-），女，内蒙古人，博士生，从事具有生物相容性薄膜的制备研究。*通讯联系人， E-mail: xzh@ecust.edu.cn

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