膜科学与技术

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ClassificationCode：TQ050

year,volume(issue):pagination： 2020,40(1):84-92

Abstract：

Hemodialysis is the main treatment method for the treatment of kidney and blood diseases. The majority of material in clinical used is polysulfone or polyethersulfone. During the dialysis process, low-molecular-weight heparin sodium and other anticoagulants are indispensable. However, high-frequency heparin injection can cause bleeding risk and various dialysis syndromes, so heparin-free or reduced-heparin dialysis is an urgently needed dialysis technique. Herein, we developed interface swelling and cross-linking, hydrophobic adsorption, and interface implantation gel three strategies to prepare self-anticoagulant dialyzers, then the surface morphology, hydrophilicity and blood compatibility (activated partial clotting enzyme time and thrombin time, protein adhesion, hemolysis rate, complement activation) of as-prepared dialyzers were characterized respectively. And animal dialysis experiments were performed to verify changes in toxin clearance by the modified dialyzer. The blood compatibility of the three modified dialyzers was significantly improved, clotting time was dramatically prolonged, protein adhesion and hemolysis were obviously decreased and complement activation was effectively inhibited. The clearance rate of the dialyzer toxin prepared by the interfacial swelling and cross-linking method decreased slightly, while the clearance rate of the dialyzer toxin prepared by the other two methods significantly improved compared with the original membrane. The advantages and disadvantages of each modification method are introduced separately, and a self-anticoagulant dialyzer with good clinical application prospect is finally prepared.

Funds：

国家自然科学基金（51973230）、浙江省杰出青年科学基金(LR20E030002)、浙江省万人计划-青年拔尖人才（ZJWR0108020）、中科院青年创新促进会优秀会员（2014258）、宁波科学技术局（2017C110034，2014B81004）

AuthorIntro：

第一作者简介：柳杨（1993-），女，山东青岛人，硕士，从事功能膜分离研究，E-mail: liuyang123@nimte.ac.cn 通信作者：刘富，E-mail：fu.liu@nimte.ac.cn

Reference：

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