膜科学与技术

发酵液中蛋白质及美拉德产物对膜的污染及其机理研究

作者：李春艳，李小青¹，江明璋¹，洪昱斌²，方永珍²

单位： 1.福建医科大学药学院，福建福州 350108；2.三达膜科技（厦门）有限公司，

关键词：蛋白质；美拉德产物；超滤；膜污染；膜阻力；膜阻力分布

出版年,卷(期):页码： 2013,33(5):14-18

摘要：

本文模拟发酵液中的蛋白质﹑美拉德产物来研究其对聚醚砜超滤膜的污染情况，主要考察污染物浓度及温度、压力等操作条件对膜污染的影响，并分析相应的总阻力﹑各部分膜阻力及其分布情况。结果表明浓度越大，膜阻力上升越快；提高操作温度和压力可一定程度地提高膜通量，但也导致膜总阻力增大，且各部分阻力及其分布情况均发生明显变化；在蛋白质中加入葡萄糖发生美拉德反应后膜阻力明显上升，污染程度大大增加

In this paper, protein and Maillard products in a simulated fermentation broth on membrane fouling of polyethersulfone Ultrafiltration membranes were studied，mainly studied the concentrations and operating temperature and pressure on Membrane fouling. Five parts of membrane resistance and its distribution were analysised. It was found that, membrane flux decreased more quickly at higher concentration, but membrane resistance increased quickly ; rising the operating temperature and pressure could increase the membrane flux , also increase resistances and the various parts of the resistance and its distribution changed significantly. Membrane resistances increased and membrane fouling increased obviously after adding the glucose into the protein and produce the Maillard reaction.

李春艳，女，博士，福建医科大学药学院教授，硕士生导师，主要从事药物活性成分分离分析研究。通讯作者：李春艳，Email:cyli65@126.com

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