膜科学与技术

PS-b-PAA/PLA有序多孔抗菌膜

作者：朱婷¹，陈海燕¹，³，徐维超¹，张明¹，²

单位： 1.扬州大学化学化工学院，扬州 225002；2.扬州大学测试中心，扬州 225009；3.扬州工业职业技术学院，扬州 225127

关键词：原子转移自由基聚合，两亲性嵌段共聚物，聚乳酸，抗菌性薄膜

出版年,卷(期):页码： 2015,35(4):1-6

摘要：

利用原子转移自由基聚合(ATRP)合成具有可控结构的嵌段共聚物PS-b-PtBA，用GPC、1HNMR对产物的分子量及其分布和嵌段组成进行了表征。将产物在酸性条件下水解得到两亲性嵌段共聚物PS-b-PAA，并用FT-IR、1HNMR和滴定分析对水解产物进行表征。用水滴模板法，以该两亲性嵌段共聚物为表面活性剂辅助聚乳酸(PLA)形成有序多孔膜，探讨PAA链长、PS-b-PAA质量分数以及溶液浓度对膜孔形貌的影响，以制备得的PS-b-PAA/PLA复合多孔膜为模板负载入抗菌剂茶多酚(TP)，制备得抗菌性薄膜，结果表明膜孔的有无以及大小会对负载的抗菌剂的量有影响，从而影响薄膜的抗菌性能。

Amphiphilic Block copolymers of polystyrene and poly(acrylic acid) were prepared by atom transfer radical polymerization techniques(ATRP). The molecular weights and polydispersities, composition, structure and hydrolytic percentage of the polymers were determined by gel permeation chromatography (GPC), 1HNMR spectra, FT-IR and titration. The as-synthesized amphiphilic PS-b-PAA was introduced to assist the fabrication of ordered porous PLA film. Several influencing factors on the morphology of film were investigated, such as the length of PAA block, the addition content of PS-b-PAA, concentration of solution and relative humidity. Then the pores of PS-b-PAA/PLA films were filled with tea polyphenol to achieve the antibacterial film whose antibacterial performance were evaluated by antibacterial ring method. The results indicated that the presence of film hole and aperture have an impact on load amount of antibacterial agent, which will effect the antibacterial performance.

朱婷（1990-），女，江苏靖江人，硕士研究生。

参考文献：

[1] Danelle B, Kok Hou W, Charles W, et al. Honeycomb-structure porous films from polypyrrole-containning block copolymers prepared via RAFT polymerization as a scaffold for cell growth[J]. Biomacromolecules, 2006, 4(7): 1072-1082.
[2] Ke Beibei, Wan Lingshu, Zhang Wenxu, et al. Controlled synthesis of linear and comb-like glycopolymers for preparation of honeycomb-patterned films[J]. Polymer, 2010, 51(10): 2168-2176.
[3] Widawski G, Rawiso M, Francois B. Self-organized honeycomb morphology of star-polymer polystyrene films[J]. Nature, 1994. 387-389
[4]兰平，李剑，龚剑亮，等. 甲醇气氛静态呼吸图法制备蜂窝状多孔膜[J]. 化学学报，2012,1(70): 45-50
[5] Li Xiaoyan, Zhao Qiaoling, Xu Tingting, et al. Highly ordered microporous polystyrene-b-poly (acrylic acid) films: Study on the influencing factors in their fabrication via a static breath-figure method[J]. European Polymer Journal, 2014, 50: 135-141.
[6] Fukuhira Y, Kitazono E, Hayashi T, et al. Biodegradable honeycomb-patterned film composed of poly (lactic acid) and dioleoylphosphatidylethanolamine[J]. Biomaterials, 2006, 27(9): 1797-1802.
[7] 孙巍. 基于水滴模板法构建微纳复合功能界面的研究[D]. 浙江大学, 2010
[8] 刘瑞来, 韩静, 陈秀娟, 等. 聚乳酸蜂窝状多孔膜的形成与控制[J]. 高分子学报, 2012 (3): 291-298.
[9] 孙巍, 沈利燕, 王家鸣, 等. 基于粒子辅助水滴模板法制备仿生复眼结构的研究[J]. 高分子学报, 2012 (10): 1151-1156.
[10] 王莹. 茶多酚的抗氧化和抑菌活性及其增效剂[J]. 生物学杂志, 2007, 24(5): 54-56.
[11] Navarro-Martínez M D, García-Cánovas F, Rodríguez-López J N. Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans[J]. Journal of Antimicrobial Chemotherapy, 2006, 57(6): 1083-1092.
[12] 王文娟, 孙京新, 罗欣, 等. 茶多酚对肉源腐败菌和致病菌的抑制效果[J]. 食品科技, 2010 (2): 102-105.
[13] Davis K A, Matyjaszewski K. Atom transfer radical polymerization of tert-butyl acrylate and preparation of block copolymers[J]. Macromolecules, 2000, 33(11): 4039-4047.

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