膜科学与技术

多巴胺的自聚-附着行为与膜表面功能化

作者：徐又一，蒋金泓，朱利平，朱宝库

单位：浙江大学高分子科学与工程学系，高分子合成与功能构造教育部重点实验室，

关键词：多巴胺；多巴；儿茶酚衍生物；功能化；仿生；表面改性

出版年,卷(期):页码： 2011,31(3):32-38

摘要：

多巴胺（dopamine）是一种生物神经递质，在水溶液条件下，它能在溶解氧的作用下发生氧化-交联反应，形成强力附着于固体材料表面的聚多巴胺复合薄层。基于多巴胺的这一特性，近年来膜技术研究者们通过多巴胺在固体基膜上的自聚-复合，对膜进行表面改性，并以具有反应活性的聚多巴胺复合层为平台，对膜进行进一步的表面修饰，实现膜的功能化。本文论述了多巴胺在膜表面修饰与功能化方面的研究进展，应用领域包括超/微滤膜、生物医用膜以及渗透汽化膜等。

Dopamine is a kind of biological neurotransmitter. In aqueous solution, it can be oxidized by dissolved oxygen and undergoes an oxidation-crosslinking reaction, forming a composite layer of polydopamine that strongly attaches to a substrate. Based on the characteristics of dopamine, in recent years, membrane technology researchers have performed surface modification via the self-polymerization-composite of dopamine on solid basement-membranes. Besides, the polydopamine composite layer with high reactivity offers a platform for further surface modification and functionalization. In this paper, research progress on modification and functionalization of membrane surface using dopamine was reviewed, the application fields included ultra/micro filtration, biomedical membranes and pervaporation film, etc.

徐又一（1945-），男，上海人，教授，从事高分子膜材料与技术研究. *通讯作者：徐又一（Email: opl-yyxu@zju.edu.cn）

参考文献：

[1] Lee H, Scherer NF, Messersmith PB. Single-molecule mechanics of mussel adhesion [J]. P Natl Acad Sci USA, 2006, 103: 12999-13003.
[2] Lee H, Dellatore SM, Miller WM, et al. Mussel-inspired surface chemistry for multifunctional coatings [J]. Science, 2007, 318: 426-430.
[3] Waite JH. Surface chemistry-mussel power [J]. Nat Mater, 2008, 7: 8-9.
[4] Sever MJ, Weisser JT, Monahan J, et al. Metal-mediated cross-linking in the generation of a marine-mussel adhesive [J]. Angew Chem Int Edit, 2004, 43: 448-450.
[5] Yu ME, Hwang JY, Deming TJ. Role of L-3,4-dihydroxyphenylalanine in mussel adhesive proteins [J]. J Am Chem Soc, 1999, 121: 5825-5826.
[6] Zhao H, Waite JH. Linking adhesive and structural proteins in the attachment plaque of mytilus californianus [J]. J Biol Chem, 2006, 281: 26150-26158.
[7] Burzio LA, Waite JH. Cross-linking in adhesive quinoproteins: studies with model decapeptides [J]. Biochemistry-US, 2000, 39: 11147-11153.
[8] van der Leeden MC. Are conformational changes, induced by osmotic pressure variations, the underlying mechanism of controlling the adhesive activity of mussel adhesive proteins [J]. Langmuir, 2005, 21: 11373-11379.
[9] Xi ZY, Xu YY, Zhu LP, et al. A facile method of surface modification for hydrophobic polymer membranes based on the adhesive behavior of polyDOPA and polydopamine [J]. J Membr Sci, 2009, 327: 244-253.
[10] Ku SH, Ryu J, Hong SK, et al. General functionalization route for cell adhesion on non-wetting surfaces [J]. Biomaterials, 2010, 31: 2535-2541.
[11] Yu F, Chen SG, Chen Y, et al. Experimental and theoretical analysis of polymerization reaction process on the polydopamine membranes and its corrosion protection properties for 304 Stainless Steel [J]. J Mol Struct, 2010, 982: 152-161.
[12] Li B, Liu WP, Jiang ZY, et al. Ultrathin and stable active layer of dense composite membrane enabled by polydopamine [J]. Langmuir, 2009, 25: 7368-7374.
[13] Pan FS, Jia HP, Qiao SZ, et al. Bioinspired fabrication of high performance composite membranes with ultrathin defect-free skin layer [J]. J Membr Sci, 2009, 341: 279-285.
[14] Kang SM, You I, Cho WK, et al. One-step modification of superhydrophobic surfaces by a mussel-inspired polymer coating [J]. Angew Chem Int Ed, 2010, 49: 9401-9404.
[15] Yu B, Liu JX, Liu SJ, et al. Pdop layer exhibiting zwitterionicity: a simple electrochemical interface for governing ion permeability [J]. Chem Commun, 2010, 46: 5900-5902.
[16] 肖琳琳, 魏雨, 计剑. 基于聚多巴胺辅助自组装单分子层技术的PTFE表面修饰及其内皮细胞选择性黏附研究 [J]. 高分子学报, 2010, 4: 479-483.
[17] Lee H, Rho J, Messersmith PB. Facile conjugation of biomolecules onto surfaces via mussel adhesive protein inspired coatings [J]. Adv Mater, 2009, 21: 431-434.
[18] McCloskey BD, Park HB, Ju H, et al. Influence of polydopamine deposition conditions on pure water flux and foulant adhesion resistance of reverse osmosis, ultrafiltration and microfiltration membranes [J]. Polymer, 2010, 51: 3472-3485.
[19] Jiang JH, Zhu LP, Li XL, et al. Surface modification of PE porous membranes based on the strong adhesion of polydopamine and covalent immobilization of heparin [J]. J Membr Sci, 2010, 364: 194-202.
[20] Li CY, Wang WC, Xu FJ, et al. Preparation of pH-sensitive membranes via dopamine-initiated atom transfer radical polymerization [J]. J Membr Sci, 2011, 367: 7-13.
[21] Liao Y, Cao B, Wang WC, et al. A facile method for preparing highly conductive and reflective surface-silvered polyimide films [J]. Appl Surf Sci, 2009, 255: 8207-8212.
[22] Liao Y, Wang YQ, Feng XX, et al. Antibacterial surfaces through dopamine functionalization and silver nanoparticle immobilization [J]. Mater Chem Phys, 2010, 121: 534-540.
[23] Guvendiren M, Messersmith PB, Shull KR. Self-assembly and adhesion of DOPA-modified methacrylic triblock hydrogels [J]. Biomacromolecules, 2008, 9: 122-128.
[24] Ou JF, Wang JQ, Zhang D, et al. Fabrication and biocompatibility investigation of TiO2 films on the polymer substrates obtained via a novel and versatile route [J]. Colloid Surf B, 2010, 76: 123-127.
[25] Fan XW, Lin LJ, Dalsin JL, et al. Biomimetic anchor for surface-initiated polymerization from metal substrates [J]. J Am Chem Soc, 2005, 127: 15843-15847.
[26] Lee H, Lee BP, Messersmith PB. A reversible wet/dry adhesive inspired by mussels and geckos [J]. Nature, 2007, 448: 338-342.
[27] Lee H, Lee Y, Statz AR, et al. Substrate-independent layer-by-layer assembly by using messel-adhesive-inspired polymers [J]. Adv Mater, 2008, 20: 1619-1623.
[28] Lee H, Lee KD, Pyo KB, et al. Catechol-grafted poly(ethylene glycol) for PEGylation on versatile substrates [J]. Langmuir, 2010, 26: 3790-3793.
[29] Bernsmann F, Ersen O, Voegel JC, et al. Melanin-containing films: growth from dopamine solutions versus layer-by-layer deposition [J]. ChemPhysChem, 2010, 11: 3299-3305.
[30] Chen J, Chen X, Yin X, et al. Bioinspired fabrication of composite pervaporation membranes with high permeation flux and structural stability [J]. J Membr Sci, 2009, 344: 136-143.

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