膜科学与技术

生物基聚乳酸微孔膜的制备及透析性能研究

作者：高爱林¹，²，刘富¹，薛立新¹

单位： 1．中国科学院宁波材料技术与工程研究所，浙江省宁波市庄市大道519号，315201；2．宁波大学材料科学与化学工程学院，浙江省宁波市江北区风华路818号，315211

关键词：聚乳酸微孔膜；浸没沉淀；生物相容性；血液透析膜

出版年,卷(期):页码： 2013,33(4):28-34

摘要：

本研究通过浸没沉淀相转化法制备了生物基聚乳酸（PLLA）微孔膜，并考察了溶剂种类和致孔剂种类及致孔剂分子量对微孔膜结构和性能的影响。具体的，分别考察了N-甲基吡咯烷酮（NMP）、N，N-二甲基乙酰胺（DMAc）和1，4-二氧六环（DO）作为溶剂对PLLA膜微孔结构的影响，研究了用聚乙二醇（PEG6000）和聚乙烯基吡咯烷酮（PVP-K30）作为致孔剂对PLLA膜微孔结构、平均孔径、水通量及接触角的影响，研究了不同分子量的致孔剂PEG（600Da、6000Da、10000Da）对PLLA膜微孔结构、平均孔径及水通量的影响。通过扫描电镜照片发现，NMP和DMAc作为溶剂可得到指状孔，而DO作为溶剂得到胞状孔，PEG和PVP-K30作为致孔剂均可促进PLLA膜大孔的形成，PVP-K30可使PLLA膜表面更为多孔，不同分子量的PEG作为致孔剂会同时影响PLLA膜的孔径和皮层厚度。通过对制备的PLLA微孔膜的水通量及尿素、溶菌酶和牛血清蛋白的透过性能分析表明聚乳酸膜具有较好的溶质选择透过性，有望成为具有良好生物相容性和透析性能的新一代血液透析膜材料。

Bio-based Poly (l-lactic acid) (PLLA) for dialysis was prepared via immersion precipitation method in this work. The influences of the solvent including N-methyl pyrrolidone (NMP), N, N-dimethyl acetamide (DMAc) and 1, 4 – dioxane on the micro-structures of PLLA membrane were investigated. The influences of the pore former including Polyethylene glycol (PEG6000) and polyvinyl Pyrrolidone (PVP) on membrane morphologies, pore size, pure water flux and contact angle were investigated. Furthermore, the influences of Polyethylene glycol with different molecular weight (e.g. PEG600, PEG6000and PEG10000) on membrane morphologies, pore size, pure water flux were also investigated. SEM pictures showed that both NMP and DMAc could produce finger-like pores for PLLA membrane, while 1, 4–dioxane could cause the formation of cellular pores. PVP-K30 can make a more porous surface than PEG6000. PEG with different molecular weight will affect both the pore size and the surface layer thickness of PLLA film. The retention of PLLA membrane to urea, lysozyme and BSA was studied to simulate the dialysis process. All results indicated that bio-based PLLA membrane is promising to be the next generation of dialysis membrane with good bio-compatibility.

高爱林（1989-），女，山东郯城人，硕士生，从事膜材料制备及应用研究。通讯联系人*，Email: fu.liu@nimte.ac.cn, xuelx@nimte.ac.cn,

参考文献：

[1] Chakrabarty, B. Ghoshal, A. K. Purkait, M. K. Effect of molecular weight of PEG on membrane morphology and transport properties. Journal of Membrane Science.2008 (309):209-221.
[2] Ma Yuxin, Shi Fengmei, Ma Ju ,Wu Miaonan ,Zhang Jun, Gao Congjie. Effect of PEG additive on the morphology and performance of polysulfone ultrafiltration membranes. Desalination. 2011(272):51-58.
[3] Ani Idris , Lee Kuan Yet. The effect of different molecular weight PEG additives on cellulose acetate asymmetric dialysis membrane performance. Journal of Membrane Science.2006(280):920-927.
[4] Susan Hanft.Ultrafiltration memnranes:technologies and the U.S.market.[R].MST044C.BBC Research,2010.
[5] Ferraz.N, D.Carlsson, O. Hong, J. Larsson. Hemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification. Journal of the Royal Society Interface. 2012(9): 1943-1955.
[6] Li Lu ,Cheng Chong Xiang, TaoTang,Min Zhao. Modification of polyethersulfone hemodialysis membrane by blending citric acid grafted polyurethane and its anticoagulant activity. Journal of Membrane Science.2012(405-406):261-274.
[7] Haitao Wang, Tian Yu, Chenyu Zhao, Qiyun Du. Improvement of hydrophilicity and blood compatibility on polyethersulfone membrane by adding polyvinylpyrrolidone。Fibers and Polymers.2009(10):1-5.
[8] 卞书森，张福港，李晓东.血液透析膜的生物相容性研究进展.中国血液净化.2006（5）:205-207.
[9] 张国栋，杨纪元，冯新德.聚乳酸的研究进展.化学进展.2000(12):89-100.
[10] T.Tanaka, D.R.Loyd. Formation of PLA microfiltration membranes via themally induced phase separation, J.Membr. Sci. 238(2004): 65-73.
[11] T.Tanaka, T.Tsuchiya, H.Formation of biodegradable polyesters membranes via thermally induced phase separation, J.Chem.Eng.Jpn. 39(2006)144-153.
[12] 贾悦，吕晓龙，武春瑞等.聚醚砜中空纤维血液透析膜的制备与透析性能初步评价.生物医学工程杂志. 2010(27):91-96.
[13] 徐又一，徐志康.高分子膜材料.化学工业出版社，北京，2005.
[14] Seong Hyun Yoo, Jong Hak Kim, Jae Young Jho, Influence of the addition of PVP on the morphology of asymmetric polyimide phase inversion membranes: effect of PVP molecular weight. Journal of Membrane Science. 2004 (236):203-207
[15] Fu Liu, N. Awanis Hashim, Yutie Liu,etc. Progress in the production and modification of PVDF membranes. Journal of Membrane Science. 2011(375):1-27.
[16] Zereshki. S,Figoli. A. Madaeni, S. S.Simone ect. Poly(lactic acid)/poly(vinyl pyrrolidone) blendmembranes: Effect of membrane composition on pervaporation separation of ethanol/cyclohexane mixture. Journal of Membrane Science. 2010(362):105-112.
[17] Sunee.Wongchitphimon, Rong.Wang, Ratana Jiraratananon etc. Effect of polyethylene glycol (PEG) as an additive on the fabrication of polyvinylidene fluoride-co-hexafluropropylene (PVDF-HFP) asymmetric microporous hollow fiber membranes. Journal of Membrane Science. 2011(369): 329-338.
[18] 徐炜，徐又一，朱宝库. 聚偏氟乙烯（PVDF）平板膜的制备工艺.2003.

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