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Study on the construction and performance of antioxidant polysulfone membrane for hemodialysis

Authors： WANG Dandan，YANG Ning，JIA Xuemeng，YUAN Guanghao，CHEN Li，ZHAO Yiping

Units： State Key Laboratory of Separation Membranes and Membrane Processes, School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin 300387, China

KeyWords： silybin-phosphatidylcholine complex, polysulfone, hemodialysis membrane, antioxidant, biocompatibility

ClassificationCode：TQ316

year,volume(issue):pagination： 2018,38(2):22-28

Abstract：

The objective of this study is to improve the antioxidant properties of polysulfone (PSF) hemodialysis membranes through hybrid silybin-phosphatidylcholine complex (SPC). The SPC/PSF hemodialysis membrane with antioxidant activity was made using PSF as membrane material by liquid-liquid phase separation method in the presence of SPC as modifier to suppress hemodialysis induced oxidative stress. For the SPC/PSF hybrid membrane，the pure water flux was increased to 187.9 ± 6.9 L / (m2h) compared with the pure PSF membrane. With the increase of the content of SPC on the membrane surface, the antioxidant properties (the ability of scavenging DPPH and ABTS free radical) were increased to 88.3 ± 1.3% and 99.4 ± 0.3%. For the SPC/PSF hybrid membrane, the stability of free radical scavenging capability under typical hemodialysis condition was good. Compared with pure PSF membrane, the SPC/PSF hybrid membrane had good cell compatibility. Compared with the pure PSF membrane, the platelet adhesion of SPC/PSF hybrid membrane was decreased, and the blood compatibility was improved. The SPC/PSF hybrid membrane had strong ability to inhibit superoxide dismutase (SOD), while pure PSF membrane stimulated the production of SOD. The results indicated that hybrid modification by SPC and PSF provided practical application of the membranes with good antioxidant properties; and a new type of SPC/PSF hemodialysis membrane was expected to be applied in the field of hemodialysis and alleviate the oxidative stress status of the patients.

Funds：

国家自然科学基金（No.31200719&21374078）, 天津市科技计划项目(15PTSYJC00250, 15JCYBJC17900, 17YFZCSF01230), 教育部创新团队项目(IRT13084)

AuthorIntro：

第一作者简介：王丹丹（1991-），女，山东枣庄人，在读硕士生，从事血液透析膜材料研究通讯作者，E-mail：summer_ningzi@163.com；Chenlis@tjpu.edu.cn

Reference：

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